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CONCLUSION The key practice priorities for nurse managers should include the design, implementation and evaluation of sustainable system-wide frameworks, processes and models of care that address patient boarding, communication and discharge processes, job satisfaction, staffing numbers and expertise. RELEVANCE TO CLINICAL PRACTICE This study provides a description of the challenges that face acute care nursing in the provision of safe and high-quality care. © 2020 John Wiley Sons Ltd.Hydroxymethylation studies on cutaneous vasc