https://www.selleckchem.com/pr....oducts/rbn013209.htm
Electroconvulsive therapy (ECT) is often recommended for major depressive disorder (MDD) for those who do not respond to the first and second antidepressant trials. A combination of two therapies could improve antidepressant efficacy. Thus, this study aimed to investigate the synergistic effects of ECT combined to antidepressants with a different mechanism of action. Rats were treated once a day, for five days with ketamine (5mg/kg), fluoxetine (1mg/kg), and bupropion (4mg/kg) alone or in combination with ECT (1mA; 100V). After, oxida
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