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A minority of these patients experience endocarditis, which is usually culture-negative due to the incapability of the causative agent, Tropheryma whipplei, to reproduce in typical microbiological culture conditions. In the emergency department, a 78-year-old man, afflicted with seronegative polyarthritis for five years, presented with a stroke, after proving resistant to several courses of biological therapies. Echocardiography
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