https://www.selleckchem.com/pr....oducts/1-phenyl-2-th
PrimPol has been recently identified as a DNA damage tolerant polymerase that plays an important role in ****tion stress response. However, the regulatory mechanisms of PrimPol are not well defined. In this study, we identify that the deubiquitinase USP36 interferes with degradation of PrimPol to regulate the ****tion stress response. Mechanistically, USP36 is deubiquitinated following DNA ****tion stress, which in turn facilitates its upregulation and interaction with PrimPol. USP36 deubiquitinates K29-linked polyu
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