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To compare the outcomes of two different antivascular endothelial growth factor treatment regimens for treatment-naive eyes with neovascular age-related macular degeneration in routine clinical care at 12 and 24 months in Spain. Observational study using the Fight Retinal Blindness (FR outcomes registry platform. Eyes were treated with fixed bimonthly (F aflibercept group at one center and a treat-and-extend (TAE) regimen using either aflibercept or ranibizumab at the other center. We included 192 eyes. Of these, 160 eyes (83%) comp