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A comparative analysis of ONFH females and males revealed 131 differentially expressed genes, comprising 76 genes with increased expression and 55 genes with decreased expression. A PPI network analysis identified 10 key hub genes, including SLC4A1, GYPA, CXCL8, IFIT1, GBP5, IFI44, IFI44L, IFIT3, KEL, and AHSP. Gene enrichment analysis indicated a strong presence of these genes within the cGMP-PKG signaling pathway, alongside pathways related to fatty acid degradation, non-alco
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