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In this paper, a novel grey decision-differential evolution (GD-DE) optimized internal model controller is proposed for the control of nonlinear aeroelastic blade system (ABS) under time-varying uncertainties and control saturations. Two-port internal model control structure is presented for saturation compensation. The filter parameter of the controller is optimally tuned by proposed GD-DE algorithm, which is designed based on the grey decision incidence theory and differential evolution algorithm. The superiority of GD-DE optimized tuni