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Hence, the pursuit of promising anticancer medications continues relentlessly. DNA's interaction with numerous essential anticancer drugs is pivotal for their biological activity. An investigation into the anticancer effects of N-ethyl toluene-4-sulphonamide (8a) and 25-Dichlorothiophene-3-sulphonamide (8b) was conducted on breast and cervical cancer cell lines. Furthermore, the research investigated how these substances en