https://mdmsignaling.com/forec....ast-regarding-handba
RMC-6272 retained its effectiveness in acquired cell lines resistant to hormone therapy and patient-derived xenografts (PDX). The drug demonstrated enhanced efficacy in CDK4/6 inhibitor-resistant cell lines compared to their respective parental counterparts. Finally, RMC-6272 was effective in a PDX model from a patient who had developed resistance to CDK4/6 inhibition. Potential effectiveness of bi-steric mTORC1-selective in
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