https://www.selleckchem.com/pr....oducts/l-histidine-m
SGLT2 inhibitors can activate SIRT-1 and and stimulate autophagy in the heart, and thereby, favorably influence the course of cardiomyopathy. Therefore, the linkage between erythrocytosis and the reduction in heart failure events with SGLT2 inhibitors may be related to a shared underlying molecular mechanism that is triggered by the action of these drugs to induce a perceived state of oxygen and nutrient deprivation. Published on behalf of the European Society of Cardiology. All rights reserved. © The A