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ediated methylation and directly inhibits channel activities. TMEM16A channel inhibition promotes endothelial cell angiogenesis. Intrinsic vitamin D affects the proliferation, apoptosis, invasion, metastasis, and tumorigenesis of lung cancer by regulating tumor signaling pathways. Histidine-rich calcium-binding protein (HRC) maintains Ca homeostasis, which plays crucial roles in the occurrence and development of cancer. Our study aims to investigate the ability of vitamin D in the regulation of HRC and the role of HRC playing in lung c