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Downregulation of ACE2 by the SARS-CoV-2 spike protein leads to excessive activation of the angiotensin II (Ang II)/angiotensin type 1 receptor pathway. The harmful effects of Ang II can be identified in the organ dysfunctions prevalent in COVID-19 patients. ACE2, the SARS-CoV-2 receptor, is extensively distributed; this widespread presence potentially accounts for the diverse sym