https://www.selleckchem.com/products/a1874.html
Twist1 is a basic helix-loop-helix transcription factor, essential during early development in mammals. While Twist1 induces Epithelial to Mesenchymal Transitions (EMT), here we show that Twist1 overexpression enhances nuclear and mitotic aberrations. This is accompanied by an increase in whole chromosomal copy number gains and losses, underscoring the role of Twist1 in inducing chromosomal instability (CIN) in colorectal cancer cells. Array Comparative Genomic Hybridisation (array CGH) analysis further shows sub-chromosomal deletions, co
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