https://www.selleckchem.com/pr....oducts/bgb-3245-brim
Magnetic circular dichroism measurements and time-dependent density functional theory calculations revealed that the broad absorption was assigned to the CT transition from the central benzene ring to the outer pyrrole rings.The outer pore of Nav1.x channels is lined by the selectivity-filter ring Asp-Glu-Lys-Ala (DEKA), an outer ring of carboxylates, and two inner rings of backbone carbonyls. A key role of Lys in the Na+/K+ selectivity is known, but the mechanism is unclear. Here, contacts involving DEKA residues in 15 cr
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