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Compared with the lowest levodopa equivalent dose quartile group (mean levodopa equivalent dose, 132mg/day), the highest group (mean levodopa equivalent dose, 973mg/day) exhibited a 68% increase in UME (17.8 vs. 30.0ng/mg cre, respectively). In addition, compared with the non-PD controls, PD patients receiving a lower levodopa equivalent dose displayed decreased UME and those receiving higher levodopa equivalent dose displayed increased UME. Our study suggests that melatonin levels in PD patients receiving average levodopa doses are com