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Using the lung-to-lung mouse model, we applied amiodarone, an off-label drug, to show that inducing autophagy promotes TIMP1 secretion and effectively suppresses the motility and metastasis of lung cancer cells in a manner reliant on RAB37. Ultimately, our research uncovered the pivotal role of RAB37 activation in regulating secretory autophagy, leading to TIMP1 release in lung cancer. For the human body to thrive and maintain its stability, cell pro