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Univariate analysis identified preoperative mechanical ventilation dependent respiratory insufficiency (p = 0.006), preoperative renal insufficiency (p = 0.019), age (p = 0.002), large vegetations (p = 0.018) as well as intermediate (p = 0.026), and late (p = 0.041) surgery as predictors of in-hospital mortality. The presence of large vegetations (8 mm) (p = 0.019) and increased age (p = 0.037)-but not operative timing-were identified as independent risk factors for in-hospital mortality. In the presence of large vegetati