https://www.selleckchem.com/pr....oducts/H-89-dihydroc
All active analogues reactivate latent HIV in a primary cell model of latency and enhance the ability of IL-15 to reactivate latent HIV in cells isolated from aviremic participants. Third, this family of compounds also promote immune effector functions in vitro in the absence of toxicity or global immune activation. Finally, initial studies in mice suggest lack of acute toxicity in vivo. A better understanding of the biological activity of these compounds will help in the design of improved LRAs that work via inhibition of
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