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In addition, most reported studies are clearly underpowered, and treatment outcomes were not standardized. CONCLUSIONS Since approximately two decades immunosuppression in pancreas transplantation mostly consists in induction with depleting antibodies and maintenance therapy using a combination of steroids, tacrolimus, and mycophenolate mofetil. While true novelty would be very much needed, this review confirms the wide use and the clinical efficacy of this regimen. Copyright© Bentham Science Publishers; For any queries, please email at