https://www.selleckchem.com/pr....oducts/pf-06650833.h
Early DNA ****tion occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA ****tion coordinates with transcription to avoid collisions and DNA damage. We develop a high-throughput nucleoside analog incorporation sequencing assay and identify thousands of early ****tion initiation zones in both mouse and human cells. The identified early ****tion initiation zones fall in open chromatin compartments and are mutually exclusive with transcription elongatio
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