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In summary, human kidney tissues display remarkable ****ual dimorphism at the molecular level. Sex-specific transcriptional signatures further shape renal cancer, with relevance for clinical management. Metformin has been associated with lower breast cancer (BC) risk and improved outcomes in observational studies. Multiple biologic mechanisms have been proposed, including a recent report of altered **** hormones. We evaluated the effect of metformin on **** hormones in MA.32, a phase III trial of nondiabetic BC subjects who were randomly assi