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Actuarial rates of new endocrinopathy were 17% at 2 yr (95% CI 10%-25%) and 31% at 5 yr (95% CI 20%-42%). On univariate analysis, **** (P=.02), gland volume (P=.03), mean gland dose (P.0001), and BED significantly predicted new hypopituitarism (P.0001). After adjusting for **** and gland volume, BED45 Gy2.47 and mean gland dose10Gy were significantly associated increased risk of hypopituitarism (hazard ratio [HR]=14.32, 95% CI=4.26-89.0, P.0001; HR=11.91, 95% CI=3.54-74.0, P.0001). BED predicted hypopituitarism mor
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