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42, 95% confidence interval 1.54-3.8. In the multivariate analysis, CAN remained almost significant after adjusting for the prognostic risk factors for CAN and the decline in the renal function, and an interaction with proteinuria was found. In analyses for the interaction effect between CAN and proteinuria, the presence of CAN synergistically increased the risk of an eGFR decline in patients with macroproteinuria. CAN strongly increased the risk of a 40% eGFR decline from baseline, especially in type2 diabetes patients with macroprot
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