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We further demonstrated that our method can be used to identify samples with **** chromosome aneuploidy, this function is validated by five Turner syndrome cases and one Klinefelter syndrome case. This proposed **** classifier not only can be used for **** predictions but also applied to identify samples with **** chromosome aneuploidy, and it is freely and easily accessible by calling the 'estimateSex' function from the newest wateRmelon Bioconductor package ( https//github.com/schalkwyk/wateRmelon ). This proposed **** classifier not only