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Individuals with HFpEFPD experience a considerable enhancement of their cardiac function when treated with SAC/VAL. The stoppage of bile flow, cholestasis, fosters the buildup of potentially harmful bile constituents inside the liver. The many organs are influenced by the action of these cytotoxic molecules. Severe lung injury, a consequence of cholestasis, can lead to the development of tissue fibrosis and respiratory distress. The presence of oxidati
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