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Can we simultaneously infer divergence times and shared demographic events? Oaks et al. introduce a full-likelihood Bayesian method based on genomic data and show that this endeavor remains challenging. Their exercise also reveals some promising avenues for future modeling attempts.Eukaryotic release factor 1 (eRF1) is a translation termination factor that binds to the ribosome at stop codons. The expression of eRF1 is strictly controlled, since its concentration defines termination efficiency and frequency of translational readthrough.