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Proteinuria can cause or exacerbate hypothyroidism, possibly due to urinary loss of protein-bound thyroid hormone. However, the precise relationship between proteinuria and hypothyroidism remains unclear. This work aimed to determine the prevalence of hypothyroidism in patients with proteinuria and the relationship between hypothyroidism and degree of proteinuria. A retrospective cohort study was conducted from December 1979 to March 2015. This study was conducted at a large academic hospital. All paired samples of urine protein and ser