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Japanese adults experienced a robust immune response and well-tolerated AZD1222. There was an observed decrease, as anticipated, in anti-SARS-CoV-2 humoral responses; spike and RBD antibody levels nevertheless, remained high. ClinicalTrials.gov provides a comprehensive database of clinical trials. The clinical trial designated as NCT04568031 demands a comprehensive approach. A study on AZD1222 in Japanese adults highlighted its immunogenicity and favorable tolerability profile. A decrease i