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Nevertheless, the full control and cure of MPE remain a distant goal, requiring a unified approach that merges clinical care and scientific research to offer hope for patients with resistant MPE. Amongst lung cancer types, non-small cell lung cancer (NSCLC) stands out as the most common and is a severe threat to human health, attributed to its exceptionally high morbidity and mortality. This research investigated the role of Notchless homolog 1 (NLE1) in the context of non-small cell lung cancer (NSCLC) development and explored the causal mechanisms. Analysis of