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Dried blood spots are popular for TDM as they are minimally invasive, allowing for self-sampling and direct shipping to a clinical laboratory using regular mail. However, blood collection techniques, such as trauma to the collection site, filter paper fragility, and hematocrit (Hct) bias can adversely affect the accuracy of the results. VAMS is a potential alternative to DBS that offers fast, volume-fixed sampling, low pain tolerance, and is not susceptible to Hct concentrations. The identification of preanalytical factors that may nega
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