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Median age at biopsy was 9 years (7-14 years). UGIE was used in 47.8% of patients (n=11), colonoscopy was used in 26.1% of patients (n=6), and direct biopsy was used in 34.8% of patients (n=8), with GVHD positive results in 2 (18.2%), 2 (33.3%), and 4 (50%) patients, respectively. Samples taken through direct biopsy stand as an effective alternative in GVHD diagnosis. Samples taken through direct biopsy stand as an effective alternative in GVHD diagnosis. The objective of this work was to compare excision with primary closure according t