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Glucose uptake by cells, particularly adipose tissue and skeletal muscle cells, depends on insulin-stimulated translocation of glucose transporter GLUT4 to the plasma membrane. The vesicle transport machinery, directed by insulin receptor signaling, carries GLUT4 vesicles from their perinuclear reservoir to the plasma membrane. Insulin signaling, in its initial stages, is segregated into multiple pathways, such as Akt/PKB and PKC-zeta/lambda. PKC-zeta/lambda activates KIF3, a motor protein functioning alon
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