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1. Although there is evidence that Cathepsin B (CTS regulates the degradation and absorption of yolk precursors during avian ovarian follicle development, nothing is known about its molecular characteristics, tissue distribution or expression profiles in goose ovarian follicular compartments.2. The intact 1023 bp coding sequence of the goose CTSB gene was obtained for the first time. It encoded a polypeptide of 340 amino acids (AA) containing two conserved functional domains (i.e., Propeptide_C1 and Peptidase_C1A_Cathpsin and three a