https://www.selleckchem.com/pr....oducts/Rapamycin.htm
In the T-2 toxin plus selenium-deficient diet group, α2 integrin expression was further decreased in the deep zone of the cartilage. Furthermore, inhibition of α2β1 integrin in C28/I2 cells could induce MMP-13 activation and type II collagen reduction, contributing to matrix degradation. These results indicate that the cytotoxic effects of T-2 toxin on chondrocyte damage and cartilage matrix degradation are associated with α2 integrin downregulation, by reducing type II collagen and MMP-13 activation.Angiotensin-converting enzyme 2 (A
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