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Crying spells and aggression were specifically associated with a moderate to severe burden. Delusion was associated with a mild to moderate and moderate to severe burden. Dysthymia and depression were associated with little or no burden to moderate to severe burden. Clinicians can provide early interventions to reduce the burden of caregivers caring for female patients with Alzheimer's disease and can refer caregivers for timely assistance to reduce their burden. Clinicians can provide early interventions to reduce the burden of caregiv