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Nonetheless, the model's black-box feedback loop approach limits proper evaluation and practical application by those without sufficient expertise. This study's intent was to examine hemodynamic responses at acupoints during acupuncture, targeting the identification of substantial shifts in critical parameters. We developed hollow near-infrared spectroscopy (NIRS) probes for real-time monitoring of oxy-hemoglobin (HbO), deoxy-hemoglobin (Hb), and blood volume (