https://www.selleckchem.com/pr....oducts/yap-tead-inhi
Cushing disease (CD) is a life-threatening disorder. Therapeutic goals include symptom relief, biochemical control, and tumor growth inhibition. Current medical therapies for CD by and large exert no action on tumor growth. To identify drugs that inhibit corticotroph tumor adrenocorticotropic hormone (ACTH) secretion and growth. High throughput screen employing a novel "gain of signal" ACTH AlphaLISA assay. Academic medical center. Corticotroph tumor tissues from patients with CD. None. Potent inhibitors of corti
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