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The function regarding Retinal Pigment Epithelial Tissues inside Regulating Macrophages/Microglial Cellular material in Retinal Immunobiology. Periodontitis may be associated with the development of head and neck cancer (HNC). A literature review was conducted to understand the possible association between them. Articles published in the PubMed database from January 1999 and May 2020 were retrieved. Limitations of the studies and biological mechanisms were discussed. A total of 4,2