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Right ventricular outflow tract dysfunction has found improved management strategies through the utilization of transcatheter pulmonary valve implantation (TPVI). Following transcatheter pulmonary valve implantation (TPVI), infective endocarditis (IE) presents a formidable challenge to the durability of the implanted valve and the favorable outcomes of the patient. Current recommendations for the treatment of TPVI-related infectious enteritis (TPVI-IE) afford only limited instruction. In this article