https://www.selleckchem.com/pr....oducts/4-Methylumbel
Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders of impaired pancreatic β cell function. The mechanisms underlying MODY include β cell KATP channel dysfunction (e.g., KCNJ11 [MODY13] or ABCC8 [MODY12] mutations); however, no other β cell channelopathies have been associated with MODY to date. Here, we have identified a nonsynonymous coding variant in KCNK16 (NM_001135105 c.341TC, p.Leu114Pro) segregating with MODY. KCNK16 is the most abundant and β cell-restricted K+ cha
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