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Water resources in Central Asia are very scarce due to natural and anthropogenic impacts. Water shortages have been a major factor hampering the socio-economic development of Central Asia. Exploring internal interactions among climate change, human activities and terrestrial hydrological cycles will help to improve the management of water resources in Central Asia. In this paper, hydro-climatic and anthropogenic data for the period 2003-2016 from the Gravity Recovery and Climate Experiment (GRACE), the Global Land Data Assimilation Sy