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Race-matched healthy individuals from the same geographic regions were used as controls for each cohort. Higher levels of gene expression of and were observed during VOC. Furthermore, plasma activity of PADI4 was higher in acute VOC when compared to healthy individuals. These results demonstrate that NETosis regulators are modulated during acute VOC, and pave the way for studies of inhibition as a therapeutic strategy for acute VOC in SCD. Higher levels of gene expression of PADI4 and ELANE were observed during VOC. Furthermore, plasma
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