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We present the preparation of self-assembled monolayers (SAMs) of pH responsive chiral periodic mesoporous organosilicas (PMOs) as model implants with drug delivery ability. SAMs of pH responsive PMOs were prepared by layer-by-layer coating of PMOs with polyelectrolytes (e.g. the enantiomers of a polycation biopolymer), for delivering organic molecules and anticancer drug molecules locally in a controlled manner to the adhered cells. We demonstrate that the amount of primary fibroblast, immortal NIH 3T3, and malignant Colo 818 cells adh
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