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As the world's largest inland shipping channel, the Yangtze River Economic Belt (YRE is strategic to China's sustainable development where policymakers are increasingly emphasizing not only this region's economic development but also its CO2 emission reduction targets. To achieve emission targets in the YREB region, it is essential to identify the driving forces of its CO2 emissions. However, existing studies are not very refined and only examine the overall effects of drivers on CO2 emission changes, while neglecting the sub-regional