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015) and 6 h post-intervention (37% higher, P = 0.133). Oxidative stress was also detectable in platelets (33% higher MFI in comparison with synthetic air at 6 h, P = 0.024; MFI 20% above baseline at 3 h, P = 0.036; 37% above baseline at 6 h, P = 0.002). ROTEM® analyses demonstrated reduced mean clotting time 1 h post-intervention compared with baseline (-4%, P = 0.049), whereas there were no significant effects on other surrogate coagulation parameters. Clinically relevant oxygen exposure induces oxidative stress in leukocytes and plate