https://www.selleckchem.com/pr....oducts/LY2228820.htm
They manifested as bradycardia or bronchospasm (38% patients), combination of bradycardia and vascular hypotension or bronchospasm (18%), or combination of 3-4 types of adverse reactions (26%); in the first and second comparison groups - in 36% and 30%, respectively ( 0.05). The most severe multifactorial adverse reactions developed due to long-term use of combinations of systemic and local β-blockers 100 mg metoprolol or 10 mg bisoprolol with 0.5% timolol. The most severe multifactorial adverse reactions developed due to long-ter