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17 versus 0.07, P=0.03) in carotid plaque ipsilateral to stroke side than women. The atrial fibrillation cohort showed no significant **** differences in plaque volumes ipsilateral to stroke. Multivariate analyses of the ESUS cohort showed male **** was associated with IPHipsi (β=0.49; 95% CI, 0.11-0.87) and calciumipsi (β=0.78; 95% CI, 0.33-1.23). Paired plaque analyses in men with ESUS showed significantly higher calcified plaque (63.9 versus 34.1 mm3, P=0.03) and a trend of higher IPHipsi (9.4 versus 7.5 mm3, P=0.73) and lipid rich nec