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93% (84/9 of the latter had a history of pregnancy (P less then 0.01), and the mean number of pregnancies was 1.5 ± 1.2 in RAI patients vs. 1.9±1.1 in controls (P less then 0.05). Most notably, infertility was observed in 23% (26/111) of RAI patients vs. 4% (4/9 of controls (P less then 0.01). In conclusion, a international observational case-control study on breast cancer after DTC in patients given RAI vs. not given RAI appears to be feasible. Additional research and everyday clinical attention should be devoted to reproductive fu
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