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The concentration of neurokinin-1 receptor was significantly decreased in the Nefopam group (P less then 0.05). Conclusion Intraperitoneally administered nefopam yielded a dose-dependent attenuation of mechanical allodynia and decreased neurokinin-1 receptor concentration, suggesting that the neurokinin-1 receptor is involved in the antiallodynic effects of nefopam in vincristine neuropathy. © 2020 Lee et al.Background and Aim Cancers originating in the breast, lung and prostate often metastasize to the bone, frequently resulting in can
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