Rheumatoid Arthritis- This form is a major crippling disorder and the most serious of the forms of arthritis. This systematically affects more than a dozen smaller joints during its course. Sufferers generally feel stiffness, fatigue, and weight-loss. Women are 3 times more likely to be affected then men. Rheumatoid Arthritis can alternate between periods of remission and exacerbation, it can be active for months or years then stop, sometimes permanently.